Last update
5/8/2025
Research Authors

Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin A (100% as Beta-Carotene)(from Blakeslea trispora and Sunflower Oil)
7,500 mcg
833%

Top Medical Research Studies

We examined a case of a 4-year-old boy who experienced severe bone pain and related symptoms after taking high doses of vitamin A for three months. Despite typical liver-related complications usually associated with vitamin A toxicity, he presented with significant musculoskeletal issues and skin changes. Following the discontinuation of vitamin A, the boy showed a remarkable recovery within two months. This case highlights that excessive vitamin A intake can lead to serious bone pain and other health problems, though he did not develop liver disease as expected.
Read More
7
ATRA shows mixed effects on pain
We explored the effects of all-trans retinoic acid (ATRA) when combined with dexamethasone and alpha-interferon in treating advanced multiple myeloma. Out of 10 treated patients, eight completed the regimen.

Notably, three experienced a stable plateau phase with improvement in their overall performance and relief from bone pain. However, only two showed a lasting partial response, while three patients did not improve.

Thus, while there was some positive impact on bone pain, further research is needed to confirm these findings and assess ATRA's full potential.
Read More

Most Useful Reviews

9
Pain relief noted
The quality is exceptional, with top ingredients. After 12 years, I’ve noticed an improvement in my joint function and relief from bone pain. The packaging is highly convenient, and the antioxidant benefits are good for the entire body. Additionally, I’ve observed enhancements in my skin, hair, and nails. The taste is neutral, making it easy to drink. I wholeheartedly recommend this product, as it significantly contributes to cognitive health and alleviates inflammation.
Read More
7.5
Bone strength improved
This product is excellent, providing wonderful benefits. It has revitalised my body and strengthened my bones. I’ve experienced noticeable relief from bone pain after using it.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.3
  • All Researches
We examined a case of a 4-year-old boy who experienced severe bone pain and related symptoms after taking high doses of vitamin A for three months. Despite typical liver-related complications usually associated with vitamin A toxicity, he presented with significant musculoskeletal issues and skin changes. Following the discontinuation of vitamin A, the boy showed a remarkable recovery within two months. This case highlights that excessive vitamin A intake can lead to serious bone pain and other health problems, though he did not develop liver disease as expected.
Read More
7
ATRA shows mixed effects on pain
We explored the effects of all-trans retinoic acid (ATRA) when combined with dexamethasone and alpha-interferon in treating advanced multiple myeloma. Out of 10 treated patients, eight completed the regimen.

Notably, three experienced a stable plateau phase with improvement in their overall performance and relief from bone pain. However, only two showed a lasting partial response, while three patients did not improve.

Thus, while there was some positive impact on bone pain, further research is needed to confirm these findings and assess ATRA's full potential.
Read More

User Reviews

USERS' SCORE
Good
Based on 2 Reviews
8.5
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Pain relief noted
The quality is exceptional, with top ingredients. After 12 years, I’ve noticed an improvement in my joint function and relief from bone pain. The packaging is highly convenient, and the antioxidant benefits are good for the entire body. Additionally, I’ve observed enhancements in my skin, hair, and nails. The taste is neutral, making it easy to drink. I wholeheartedly recommend this product, as it significantly contributes to cognitive health and alleviates inflammation.
Read More
7.5
Bone strength improved
This product is excellent, providing wonderful benefits. It has revitalised my body and strengthened my bones. I’ve experienced noticeable relief from bone pain after using it.
Read More

Frequently Asked Questions

No FAQs are available for this product and symptom.

References

  1. Baineni R, Gulati R, Delhi CK. Vitamin A toxicity presenting as bone pain. Arch Dis Child. 2017;102:556. 10.1136/archdischild-2016-310631
  2. Musto P, Sajeva MR, Sanpaolo G, D'Arena G, Scalzulli PR, et al. All-trans retinoic acid in combination with alpha-interferon and dexamethasone for advanced multiple myeloma. Haematologica. 1997;82:354.
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